Physical Specimen Expansion

Enabling 3-D Large Volume, Nanoscale Imaging

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Welcome to the site for expansion microscopy protocols.

Here you can find relevant papers, protocols, materials lists, and advice on expansion microscopy (ExM), a new concept for imaging biological specimens with fine detail by physically making them bigger through a chemical process that preserves nanoscale isotropy. It enables super-resolution imaging on a conventional light microscope.

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References and Links

Chen, F.*, Tillberg, P.W.*, Boyden, E.S. (2015) Expansion Microscopy, Science 347(6221):543-548. (*, equal contribution) [Publisher link] [PDF]